File(s) under permanent embargo

Reason: This item is currently closed access.

Characterisation of the properdin-deficient immune phenotype

journal contribution
posted on 26.04.2019, 10:29 by Fatima Mohamed Makhlouf Mohamed, Cordula M. Stover
Properdin (complement factor P) is a conserved serum glycoprotein of the immune defence. It plays a role in strengthening the activation of complement, a system of proteins important in the first line defence against infection. Properdin is active in the alternative pathway of complement within the innate immune system. It is the sole regulator of complement activation and plays a major role in regulating the alternative pathway by binding to and stabilising the inherently labile C3 convertase enzymes, C3bBb and C3bBbC3b. The properdin-deficient mouse line was used in various studies in order to investigate the role of properdin in disease models of immunity, infection and inflammation. It was shown that properdin controls the strength of immune responses by affecting both humoral and cellular phenotypes during acute bacterial infection and resulting inflammation. A clear overview of the measurements for which properdin-deficient and wild-type mice are similar or different in their unstimulated state is lacking. This review shows the cumulative analysis in mouse regarding the effect of properdin-deficiency on baseline immune measurements, and will consider all studies on properdin-deficient and wild-type mice, where inflammatory cellular or humoral mediators, activities and metabolism were measured. The analysis lends support to the concept that systemic therapeutic targeting of properdin may influence properdin-dependent cellular crosstalks within tissues.

History

Citation

Current Trends in Immunology, 2018, 19, pp. 83-96

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

Current Trends in Immunology

Publisher

Research Trends

issn

0972-4567

Copyright date

2018

Publisher version

http://www.researchtrends.net/tia/abstract.asp?in=0&vn=19&tid=36&aid=6229&pub=2018&type=

Notes

The file associated with this record is under a permanent embargo in accordance with the publisher's policy. The full text may be available through the publisher links provided above.

Language

en

Usage metrics

Categories

Keywords

Exports