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Chromatin fiber structural motifs as regulatory hubs of genome function?

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journal contribution
posted on 20.06.2019, 12:50 by Manuela Moraru, Thomas Schalch
Nucleosomes cover eukaryotic genomes like beads on a string and play a central role in regulating genome function. Isolated strings of nucleosomes have the potential to compact and form higher order chromatin structures, such as the well-characterized 30-nm fiber. However, despite tremendous advances in observing chromatin fibers in situ it has not been possible to confirm that regularly ordered fibers represent a prevalent structural level in the folding of chromosomes. Instead, it appears that folding at a larger scale than the nucleosome involves a variety of random structures with fractal characteristics. Nevertheless, recent progress provides evidence for the existence of structural motifs in chromatin fibers, potentially localized to strategic sites in the genome. Here we review the current understanding of chromatin fiber folding and the emerging roles that oligonucleosomal motifs play in the regulation of genome function.

Funding

This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) [grant number BB/R016275/1].

History

Citation

Essays in Biochemistry, 2019, 63(1), pp. 123-132

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Molecular & Cell Biology

Version

VoR (Version of Record)

Published in

Essays in Biochemistry

Publisher

Portland Press for Biochemical Society

eissn

1744-1358

Acceptance date

13/03/2019

Copyright date

2019

Available date

20/06/2019

Publisher version

http://essays.biochemistry.org/content/63/1/123

Language

en