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Cohort Profile: The Chongqing Longitudinal Twin Study (LoTiS)

journal contribution
posted on 12.05.2022, 10:28 by Chao Tong, Li Wen, Lan Wang, Xin Fan, Yan Zhao, Yamin Liu, Xing Wang, Shuai Huang, Junnan Li, Jie Li, Longqiong Wang, Jie Gan, Lian Yu, Lianlian Wang, Huisheng Ge, Chengjin He, Jiaxiao Yu, Tianjiao Liu, Xiyao Liu, Yang Yang, Xin Li, Huili Jin, Youwen Mei, Jing Tian, Pamela Leong, Mark D Kilby, Hongbo Qi, Richard Saffery, Philip N Baker

We aim to define the relative contribution of genetic factors and the environment to early onset morbidity of infancy and to identify specific ‘biomarkers’ and critical time points from pregnancy onwards for emergence of differences in illness in infancy-associated phenotypes, by establishing a longitudinal twin pregnancy birth cohort.


The Chongqing Longitudinal Twin Study (LoTiS) cohort was established in January 2016 at Chongqing, China, with the aim of enrolling 300 women, aged 20–40 years, pregnant with twins, and their offspring. The women were followed up in early, middle and late pregnancy and at delivery, and their offspring were followed up at birth, 6 weeks and 3, 6, 12, 18, 24, 30 and 36months of age. Currently, there were 439 participants recruited and 333 completed the visits during pregnancy.


Maternal social demography, laboratory examinations, perinatal outcomes, neonatal outcomes, infantile growth data and assessment were collected.


The study collaborated with Murdoch Children’s Research Institute, Royal Children's Hospital, Australia and the University of Birmingham, UK. Data were assessed at the website: [https://www.medscinet.com/Lotis/empty.aspx].

Funding

National Key Research and Development Program of China (grant number 2018YFC1002900)

National Natural Science Foundation of China (grant number 81520108013)

History

Citation

International Journal of Epidemiology, dyab264, https://doi.org/10.1093/ije/dyab264

Author affiliation

College of Life Sciences, University of Leicester

Version

AM (Accepted Manuscript)

Published in

International journal of epidemiology

Publisher

Oxford University Press (OUP)

issn

0300-5771

eissn

1464-3685

Acceptance date

10/12/2021

Copyright date

2022

Available date

20/01/2023

Spatial coverage

England

Language

eng

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