Competing interests in a lung cancer with metastasis to the pituitary gland: syndrome of inappropriate ADH secretion versus diabetes insipidus.pdf (542.15 kB)
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Competing interests in a lung cancer with metastasis to the pituitary gland: syndrome of inappropriate ADH secretion versus diabetes insipidus.

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journal contribution
posted on 29.08.2019, 14:32 by Gaurav Singh Gulsin, Madeleine Louisa Bryson Jacobs, Shailesh Gohil, Adam Thomas, Miles Levy
Metastases to the pituitary gland are rare; cancers that most commonly metastasize to the pituitary are breast and lung cancers. No specific computed tomography or magnetic resonance imaging features reliably distinguish primary pituitary masses from metastases. A combination of a detailed clinical assessment together with specialist endocrine and neuroradiology support is essential to make the rare diagnosis of a pituitary metastasis. We present the case of a man with metastatic lung cancer, initially presenting as hypopituitarism. Subtle features in the history, together with neuroimaging findings atypical for pituitary adenomas, provided clues that the diagnosis was one of the pituitary metastases. Treatment of diabetes insipidus (DI) with replacement antidiuretic hormone (ADH) was complicated by extreme difficulties in achieving a satisfactory sodium and water balance. This was the result of coexistent DI and syndrome of inappropriate ADH secretion perpetuated by the patient's primary lung cancer, a phenomenon not previously described in the literature.

History

Citation

Oxford Medical Case Reports, 2016, 2016(6), pp. 125–129.

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

Oxford Medical Case Reports

Publisher

Oxford University Press (OUP)

issn

2053-8855

Acceptance date

10/05/2016

Copyright date

2016

Available date

29/08/2019

Publisher version

https://academic.oup.com/omcr/article/2016/6/125/2362366

Language

en