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Computational diagnosis of canine lymphoma

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journal contribution
posted on 27.04.2015, 14:00 by E. M. Mirkes, I. Alexandrakis, K. Slater, R. Tuli, A. N. Gorban
One out of four dogs will develop cancer in their lifetime and 20% of those will be lymphoma cases. PetScreen developed a lymphoma blood test using serum samples collected from several veterinary practices. The samples were fractionated and analysed by mass spectrometry. Two protein peaks, with the highest diagnostic power, were selected and further identified as acute phase proteins, C-Reactive Protein and Haptoglobin. Data mining methods were then applied to the collected data for the development of an online computer-assisted veterinary diagnostic tool. The generated software can be used as a diagnostic, monitoring and screening tool. Initially, the diagnosis of lymphoma was formulated as a classification problem and then later refined as a lymphoma risk estimation. Three methods, decision trees, kNN and probability density evaluation, were used for classification and risk estimation and several preprocessing approaches were implemented to create the diagnostic system. For the differential diagnosis the best solution gave a sensitivity and specificity of 83.5% and 77%, respectively (using three input features, CRP, Haptoglobin and standard clinical symptom). For the screening task, the decision tree method provided the best result, with sensitivity and specificity of 81.4% and >99%, respectively (using the same input features). Furthermore, the development and application of new techniques for the generation of risk maps allowed their user-friendly visualization.

History

Citation

Journal of Physics: Conference Series 490 (2014) 012135

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Mathematics

Source

2nd International Conference on Mathematical Modeling in Physical Sciences 2013 (IC-MSQUARE 2013)

Version

VoR (Version of Record)

Published in

Journal of Physics: Conference Series 490 (2014) 012135

Publisher

IOP PUBLISHING LTD

issn

1742-6588

eissn

1742-6596

Available date

27/04/2015

Publisher version

http://iopscience.iop.org/1742-6596/490/1/012135/

Editors

Vagenas, E. C.;Vlachos, D. S.

Language

en