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Critique of the "Comment" etitled "Pyrethroid exposure: Not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology
journal contributionposted on 13.10.2021, 09:44 by Frank A Barile, Sir Colin Berry, Bas Blaauboer, Alan Boobis, Herrmann Bolt, Christopher J Borgert, Wolfgang Dekant, Daniel Dietrich, Jose L Domingo, Gio Batta Gori, Helmut Greim, Jan Hengstler, Sam Kacew, Hans Marquardt, Olavi Pelkonen, Kai Savolainen, Pat Heslop-Harrison, Aristides Tsatsakis, Nico P Vermeulen
Recently, The Lancet published a “Comment” with the title “Pyrethroid exposure: not so harmless after all” (Demeneix et al., 2020). We were surprised to see such a speculative article published by The Lancet. There is no critical evaluation of how the limited number of references (10) cited support – or failed to support - the authors’ unjustified conclusions. The Editor of the Lancet and the manuscript reviewers seem to have made the naive assumption that the mere existence of a putatively hazardous substance in the human body invites restrictive regulation. The article may cause unwarranted public anxiety. Perhaps more importantly, this misguided position fails to satisfy the need for risk assessment which follows hazard identification and is the core of responsible regulatory policy.
The Lancet choose not to publish our criticism of their article. Thus, we are glad to have the opportunity to publish it in Toxicology Letters.