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DJ-1 in Parkinson's Disease: Clinical Insights and Therapeutic Perspectives.

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posted on 18.09.2019, 09:08 by Mariaelena Repici, Flaviano Giorgini
Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

Funding

M.R. is supported by funding from the Wellcome Trust (WT-ISSF, University of Leicester). F.G. acknowledges support from the Medical Research Council (MRC) and Parkinson’s UK for DJ-1 related research in his laboratory.

History

Citation

Journal of Clinical Medicine, 2019, 8(9), 1377;

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology

Version

VoR (Version of Record)

Published in

Journal of Clinical Medicine

Publisher

MDPI

issn

2077-0383

Acceptance date

30/08/2019

Copyright date

2019

Available date

18/09/2019

Publisher version

https://www.mdpi.com/2077-0383/8/9/1377

Language

en

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