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Deciphering Functions of Intracellular Formaldehyde - Linking Cancer and Aldehyde Metabolism

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journal contribution
posted on 29.01.2018, 16:03 by Richard J. Hopkinson, Christopher J. Schofield
[First paragraph]Formaldehyde, the simplest aldehyde, is an environmental pollutant and human toxin. Acute exposure to exogenous formaldehyde can cause irritation, nausea, renal failure, and coma. Chronic formaldehyde exposure correlates with increased cancer incidence, in particular of nasopharyngeal cancer and leukemia. In addition to exogenous sources, formaldehyde is produced endogenously in cells; eukaryotic pathways producing formaldehyde include xenobiotic metabolism and enzyme-catalyzed N-methyl demethylation of the N-methylated histone and DNA components of chromatin, as well as of RNA. Thus, endogenously produced formaldehyde may have biological roles; there have been very few studies connecting the biochemistry of formaldehyde with physiology.

Funding

The authors thank the Biotechnology and Biological Sciences Research Council (BB/E527620/1), Cancer Research UK (C8717/A18245), and the Wellcome Trust (091857/7/10/7) for funding our work with formaldehyde. R.J.H. acknowledges a William R. Miller Junior Research Fellowship, St. Edmund Hall, Oxford, U.K.

History

Citation

Biochemistry, 2018

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry

Version

AM (Accepted Manuscript)

Published in

Biochemistry

Publisher

American Chemical Society

issn

0006-2960

eissn

1520-4995

Acceptance date

11/01/2018

Copyright date

2018

Available date

25/01/2019

Publisher version

http://pubs.acs.org/doi/10.1021/acs.biochem.7b01304

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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