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Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice

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journal contribution
posted on 06.05.2022, 11:04 by David S Hains, Shamik Polley, Dong Liang, Vijay Saxena, Samuel Arregui, John Ketz, Evan Barr-Beare, Ashley Rawson, John D Spencer, Ariel Cohen, Pernille L Hansen, Martina Tuttolomondo, Cinzia Casella, Henrik J Ditzel, Daniel Cohen, Edward J Hollox, Andrew L Schwaderer

Letter to Editor:  We identify that children with a history of urinary tract infections (UTIs) and vesicoureteral reflux (VUR) with low deleted in Malignant Brain Tumors 1 (DMBT1) DNA copy number have ∼4‐fold higher odds of recurrent UTIs compared to those with high DMBT1 DNA copy number. With bacterial resistance to antibiotics increasing, we need to develop new strategies to guide judicious use of antibiotics such as using the patient's genetic profile.

Funding

The work was supported by grants from the United States National Institutes of Health (NIDDK), (grant numbers: R01DK106286 and 1RC4DK090937).

History

Citation

Hains DS, Polley S, Liang D, Saxena V, Arregui S, Ketz J, Barr-Beare E, Rawson A, Spencer JD, Cohen A, Hansen PL, Tuttolomondo M, Casella C, Ditzel HJ, Cohen D, Hollox EJ, Schwaderer AL. Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice. Clin Transl Med. 2021 Jul;11(7):e477. doi: 10.1002/ctm2.477.

Author affiliation

Department of Genetics and Genome Biology

Version

VoR (Version of Record)

Published in

Clinical and Translational Medicine

Volume

11

Issue

7

Pagination

e477

Publisher

Wiley Open Access

issn

2001-1326

eissn

2001-1326

Acceptance date

08/06/2021

Copyright date

2021

Available date

04/07/2021

Language

English