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Detection of multiple fluorescent labels using superconducting tunnel junction detectors.

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journal contribution
posted on 30.05.2007, 11:25 by G. W. Fraser, J. S. (Pat) Heslop-Harrison, T. Schwarzacher, A. D. Holland, P. Verhoeve, A. Peacock
We show that cryogenically cooled, photon counting superconducting tunnel junctions ~STJs! can be used to simultaneously record the optical spectra from multiple biological fluorochromes. Measurements with a single-pixel tantalum STJ with a wavelength resolving power R5l/Dl of about 10 confirm the expected sensitivity advantage with respect to the photomultiplier-based detectors commonly used to record signals from microarrays and other fluorescent biological systems.

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Citation

Review of Scientific Instruments, 2003, 74 (9), pp. 4140-4144

Published in

Review of Scientific Instruments

Publisher

American Institute of Physics

issn

0034-6748

eissn

1089-7623

Available date

30/05/2007

Notes

This is the version as published by American Instiitute of physics. It is available online at http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=RSINAK000074000009004140000001&idtype=cvips&gifs=yes

Language

en

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