File(s) under embargo

Reason: 12 month publisher embargo

4

month(s)

1

day(s)

until file(s) become available

Determinants of cerebral blood flow velocity changes during squat-stand maneuvers.

journal contribution
posted on 04.05.2021, 09:49 by Ronney B Panerai, Angus Batterham, Thompson G Robinson, Victoria J Haunton
The large changes in mean arterial blood pressure (MABP) and cerebral blood flow velocity (CBFV) induced by squat-stand maneuvers (SSM) make this approach particularly suited for studying dynamic cerebral autoregulation (CA). However, the role of other systemic determinants of CBFV has not been described and could provide alternative physiological interpretations of SSM results. In 32 healthy subjects (16 female), continuous recordings of MABP (Finometer), bilateral CBFV (transcranial Doppler, MCA), end-tidal CO2 (EtCO2, capnography) and heart rate (HR, electrocardiogram) were performed for five min standing at rest, and during fifteen SSM at the frequency of 0.05 Hz. A time-domain, multivariate dynamic model estimated the CBFV variance explained by different inputs, corresponding to significant contributions from MABP (p<0.00001), EtCO2 (p<0.0001) and HR (p=0.041). The autoregulation index (ARI, range 0-9) was estimated from the CBFV response to a step change in MABP. At rest, ARI values (typically 5.7) were independent of the number of model inputs, but during SSM, ARI was reduced compared to baseline (p<0.0001), and the three input model yielded lower values for the right and left MCA (3.4 ± 1.2, 3.1 ± 1.3) when compared to the single input MABP-CBFV model (4.1 ± 1.1, 3.9 ± 1.0; p<0.0001). The high coherence of the MABP-CBFV transfer function at 0.05 Hz (typically 0.98) was considerably reduced (around 0.71-0.73; p<0.0001) when the contribution of CBFV co-variates was taken into account. Not taking into consideration other determinants of CBFV, in addition to MABP, could be misleading and introduce biases in physiological and clinical studies.

History

Citation

American journal of physiology, Volume 320, Issue 4, April 2021, pp. R452-R466

Published in

American journal of physiology. Regulatory, integrative and comparative physiology

Volume

320

Issue

4

Pagination

R452 - R466

Publisher

American Physiological Society

issn

0363-6119

eissn

1522-1490

Acceptance date

01/02/2021

Copyright date

2021

Available date

01/04/2022

Spatial coverage

United States

Language

eng