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Development of a computationally-designed polymeric adsorbent specific for mycotoxin patulin.

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journal contribution
posted on 06.02.2019, 15:40 by EV Piletska, D Pink, K Karim, SA Piletsky
Patulin is a toxic compound which is found predominantly in apples affected by mould rot. Since apples and apple-containing products are a popular food for the elderly, children and babies, the monitoring of the toxin is crucial. This paper describes a development of a computationally-designed polymeric adsorbent for the solid-phase extraction of patulin, which provides an effective clean-up of the food samples and allows the detection and accurate quantification of patulin levels present in apple juice using conventional chromatography methods. The developed bespoke polymer demonstrates a quantitative binding towards the patulin present in undiluted apple juice. The polymer is inexpensive and easy to mass-produce. The contributing factors to the function of the adsorbent is a combination of acidic and basic functional monomers producing a zwitterionic complex in the solution that formed stronger binding complexes with the patulin molecule. The protocols described in this paper provide a blueprint for the development of polymeric adsorbents for other toxins or different food matrices.

History

Citation

Analyst, 2017, 142 (24), pp. 4678-4683

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry

Version

AM (Accepted Manuscript)

Published in

Analyst

Publisher

Royal Society of Chemistry

eissn

1364-5528

Acceptance date

06/11/2017

Copyright date

2017

Available date

06/02/2019

Publisher version

https://pubs.rsc.org/en/Content/ArticleLanding/2017/AN/C7AN01294B#!divAbstract

Language

en