Dilated Cardiomyopathy: Phosphorus 31 MR Spectroscopy at 7 T.pdf (581.02 kB)
Download file

Dilated Cardiomyopathy: Phosphorus 31 MR Spectroscopy at 7 T

Download (581.02 kB)
journal contribution
posted on 01.05.2018, 10:06 by V. M. Stoll, W. T. Clarke, Eylem Levelt, A. Liu, S. G. Myerson, M. D. Robson, S. Neubauer, C. T. Rodgers
Purpose: To test whether the increased signal-to-noise ratio of phosphorus 31 (31P) magnetic resonance (MR) spectroscopy at 7 T improves precision in cardiac metabolite quantification in patients with dilated cardiomyopathy (DCM) compared with that at 3 T. Materials and Methods: Ethical approval was obtained, and participants provided written informe consent. In a prospective study, 31P MR spectroscopy was performed at 3 T and 7 T in 25 patients with DCM. Ten healthy matched control subjects underwent 31P MR spectroscopy at 7 T. Paired Student t tests were performed to compare results between the 3-T and 7-T studies. Results: The phosphocreatine (PCr) signal-to-noise ratio increased 2.5 times at 7 T compared with that at 3 T. The PCr to adenosine triphosphate (ATP) concentration ratio (PCr/ATP) was similar at both field strengths (mean ± standard deviation, 1.48 ± 0.44 at 3 T vs 1.54 ± 0.39 at 7 T, P = .49), as expected. The Cramér-Rao lower bounds in PCr concentration (a measure of uncertainty in the measured ratio) were 45% lower at 7 T than at 3 T, reflecting the higher quality of 7-T 31P spectra. Patients with dilated cardioyopathy had a significantly lower PCr/ATP than did healthy control subjects at 7 T (1.54 ± 0.39 vs 1.95 ± 0.25, P = .005), which is consistent with previous findings. Conclusion: 7-T cardiac 31P MR spectroscopy is feasible in patients with DCM and gives higher signal-to-noise ratios and more precise quantification of the PCr/ATP than that at 3 T. PCr/ATP was significantly lower in patients with DCM than in control subjects at 7 T, which is consistent with previous findings at lower field strengths.

History

Citation

Radiology, 2016, 281 (2), pp. 409-417

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

Radiology

Publisher

Radiological Society of North America

issn

0033-8419

eissn

1527-1315

Acceptance date

28/03/2016

Copyright date

2016

Available date

01/05/2018

Publisher version

https://pubs.rsna.org/doi/10.1148/radiol.2016152629

Language

en