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Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats

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journal contribution
posted on 22.02.2016, 10:21 by Andrew M. J. Young, C. Stubbendorff, M. Valencia, T. V. Gerdjikov
Subchronic treatment with the N-methyl-D-aspartate (NMDA) antagonist phencyclidine (PCP) produces behavioral abnormalities in rodents which are considered a reliable pharmacological model of neurocognitive deficits in schizophrenia. Alterations in prefrontal neuronal firing after acute PCP administration have been observed, however enduring changes in prefrontal activity after subchronic PCP treatment have not been studied. To address this we have recorded cortical oscillations and unit responses in putative cortical pyramidal cells in subchronic PCP-treated rats (2mg/kg twice daily for 7 days) under urethane anesthesia. We found that this regimen reduced theta oscillations in the medial prefrontal cortex. It further produced abnormal cortical synchronization in putative cortical pyramidal cells. These alterations in prefrontal cortex functioning may contribute to cognitive deficits seen in subchronic NMDA antagonist pre-treated animals in prefrontal-dependent tasks.

History

Citation

Neuroscience, 2015, 287, pp. 157-163

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

Neuroscience

Publisher

Elsevier for Pergamon

issn

0306-4522

eissn

1873-7544

Acceptance date

11/12/2014

Copyright date

2014

Available date

22/02/2016

Publisher version

http://www.sciencedirect.com/science/article/pii/S0306452214010562

Language

en