Does autocrine growth factor secretion form part of a mechanism which paradoxically protects against tumour development?.pdf (1.19 MB)
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Does autocrine growth factor secretion form part of a mechanism which paradoxically protects against tumour development?

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journal contribution
posted on 15.12.2016, 11:11 by T. Dawson, D. Wynford-Thomas
Autocrine growth factor secretion has classically been considered as a mechanism by which tumour cells achieve autonomous growth. However, there is now considerable evidence that autocrine circuits operate in the growth regulation of normal adult tissues. Here we consider the possible advantages to the normal epithelial cell of utilising such an external growth factor circuit and suggest that autocrine growth factor secretion, when viewed in a multicellular context, could paradoxically form part of a mechanism for preventing tumour development.

Funding

This work was supported by the UK Cancer Research Campaign and the Welsh Scheme for the Development of Health and Social Research.

History

Citation

British Journal of Cancer (1995) 71, 1136–1141.

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine

Version

VoR (Version of Record)

Published in

British Journal of Cancer (1995) 71

Publisher

Cancer Research UK, Nature Publishing Group

issn

0007-0920

eissn

1532-1827

Available date

15/12/2016

Publisher version

http://www.nature.com/bjc/journal/v71/n6/abs/bjc1995222a.html

Language

en