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Dynamic Cerebral Autoregulation Reproducibility Is Affected by Physiological Variability

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posted on 05.08.2019 by ML Sanders, JWJ Elting, RB Panerai, M Aries, E Bor-Seng-Shu, A Caicedo, M Chacon, ED Gommers, S Van Huffel, JL Jara, K Kostoglou, A Mandi, VZ Marmarelis, GD Mitsis, M Muller, D Nikolic, RC Nogueira, SJ Payne, C Puppo, DC Shin, DM Simpson, T Tarumi, B Yelicich, R Zhangs, JAHR Claassen
Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility. In an international, multi-center study, we evaluated the influence of multiple analytical methods on the reproducibility of DCA. Fourteen participating centers analyzed repeated measurements from 75 healthy subjects, consisting of 5 min of spontaneous fluctuations in blood pressure and cerebral blood flow velocity signals, based on their usual methods of analysis. DCA methods were grouped into three broad categories, depending on output types: (1) transfer function analysis (TFA); (2) autoregulation index (ARI); and (3) correlation coefficient. Only TFA gain in the low frequency (LF) band showed good reproducibility in approximately half of the estimates of gain, defined as an intraclass correlation coefficient (ICC) of >0.6. None of the other DCA metrics had good reproducibility. For TFA-like and ARI-like methods, ICCs were lower than values obtained with surrogate data (p < 0.05). For TFA-like methods, ICCs were lower for the very LF band (gain 0.38 ± 0.057, phase 0.17 ± 0.13) than for LF band (gain 0.59 ± 0.078, phase 0.39 ± 0.11, p ≤ 0.001 for both gain and phase). For ARI-like methods, the mean ICC was 0.30 ± 0.12 and for the correlation methods 0.24 ± 0.23. Based on comparisons with ICC estimates obtained from surrogate data, we conclude that physiological variability or non-stationarity is likely to be the main reason for the poor reproducibility of DCA parameters.

History

Citation

Frontiers in Physiology, 2019, 10:865

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

Frontiers in Physiology

Publisher

Frontiers Media

issn

1664-042X

Acceptance date

20/06/2019

Copyright date

2019

Available date

05/08/2019

Publisher version

https://www.frontiersin.org/articles/10.3389/fphys.2019.00865/full

Notes

The datasets generated for this study are available on request to the corresponding author. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphys.2019.00865/full#supplementary-material

Language

en

Licence

Exports