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Effects of statins on delirium following cardiac surgery - evidence from literature.

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journal contribution
posted on 31.07.2017, 13:53 by Giovanni Mariscalco, Silvia Mariani, Fausto Biancari, Maciej Banach
Delirium is a common complication after cardiac surgery, being associated with significant mortality and morbidity. The pathogenesis of postoperative delirium (POD) is complex and multifactorial, involving an interaction of multiple predisposing and precipitating factors. There are several hypothesis regarding the underlying mechanisms of POD, and the most recent emerging one involves neuroinflammation, which is exacerbated by the cardiopulmonary bypass-induced systemic inflammatory response. Experimental and clinical studies have recently documented improved perioperative central neural protection exerted by statins because of their anti-inflammatory, immunomodulatory, and antithrombotic properties. The present review will focused on the possible protective effect exerted by preoperative statin administration on delirium following cardiac surgery.

History

Citation

Psychiatria Polska, 2015, 49 (6), pp. 1359-1370

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

Psychiatria Polska

Publisher

Polskie Towarzystwo Psychiatryczne

issn

0033-2674

eissn

2391-5854

Copyright date

2015

Available date

31/07/2017

Publisher version

http://www.psychiatriapolska.pl/1359_1370

Language

en

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