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Enhanced avoidance habits in obsessive-compulsive disorder

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journal contribution
posted on 24.02.2016, 11:56 by C. M. Gillan, S. Morein-Zamir, Gonzalo Pablo Urcelay, A. Sule, V. Voon, A. M. Apergis-Schoute, N. A. Fineberg, B. J. Sahakian, T. W. Robbins
BACKGROUND: Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensitive to goal value. We tested if OCD patients have a bias toward habits using a novel shock avoidance task. To explore how habits, as a putative model of compulsivity, might relate to obsessions and anxiety, we recorded measures of contingency knowledge, explicit fear, and physiological arousal. METHODS: Twenty-five OCD patients and 25 control subjects completed a shock avoidance task designed to induce habits through overtraining, which were identified using goal-devaluation. The relationship between habitual behavior, erroneous cognitions, and physiological arousal was assessed using behavior, questionnaires, subjective report, and skin conductance responses. RESULTS: A devaluation sensitivity test revealed that both groups could inhibit unnecessary behavioral responses before overtraining. Following overtraining, OCD patients showed greater avoidance habits than control subjects. Groups did not differ in conditioned arousal (skin conductance responses) at any stage. Additionally, groups did not differ in contingency knowledge or explicit ratings of shock expectancy following the habit test. Habit responses were associated with a subjective urge to respond. CONCLUSIONS: These data indicate that OCD patients have a tendency to develop excessive avoidance habits, providing support for a habit account of OCD. Future research is needed to fully characterize the causal role of physiological arousal and explicit fear in habit formation in OCD.

History

Citation

Biological Psychiatry, 2014, 75 (8), pp. 631-638

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

Biological Psychiatry

Publisher

Elsevier for Society of Biological Psychiatry

issn

0006-3223

eissn

1873-2402

Acceptance date

07/02/2013

Copyright date

2014

Available date

24/02/2016

Publisher version

http://www.sciencedirect.com/science/article/pii/S0006322313001455

Language

en