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Exercise Intolerance in Heart Failure with Preserved Ejection Fraction

journal contribution
posted on 13.07.2021, 14:57 by Andrea Salzano, Mariarosaria De Luca, Muhammad Zubair Israr, Giulia Crisci, Mohamed Eltayeb, Radek Debiec, Brigida Ranieri, Roberta D'Assante, Salvatore Rega, Anna D'Agostino, Ciro Mauro, Iain B Squire, Toru Suzuki, Eduardo Bossone, Marco Guazzi, Alberto M Marra
Exercise intolerance represents a typical feature of heart failure with preserved ejection fraction (HFpEF), and is associated with a poor quality of life, frequent hospitalizations, and increased all-cause mortality. The cardiopulmonary exercise test is the best method to quantify exercise intolerance, and allows detection of the main mechanism responsible for the exercise limitation, influencing treatment and prognosis. Exercise training programs improve exercise tolerance in HFpEF. However, studies are needed to identify appropriate type and duration. This article discusses the pathophysiology of exercise limitation in HFpEF, describes methods of determining exercise tolerance class, and evaluates prognostic implications and potential therapeutic strategies.

History

Citation

Heart Failure Clinics Volume 17, Issue 3, July 2021, Pages 397-413

Author affiliation

Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

Heart Failure Clinics

Volume

17

Issue

3

Pagination

397 - 413

Publisher

Elsevier

issn

1551-7136

Copyright date

2021

Spatial coverage

United States

Language

English