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Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies.

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journal contribution
posted on 19.11.2020, 14:44 by Anam Asad, James O Burton, Daniel S March
Acute kidney injury (AKI) is a known risk factor for chronic kidney disease (CKD) and end stage kidney disease (ESKD). The progression from AKI to CKD, despite being well recognised, is not completely understood, although sustained inflammation and fibrosis are implicated. A therapeutic intervention targeting the post AKI stage could reduce the progression to CKD, which has high levels of associated morbidity and mortality. Exercise has known anti-inflammatory effects with animal AKI models demonstrating its use as a therapeutic agent in abrogating renal injury. This suggests the use of an exercise rehabilitation programme in AKI patients following discharge could attenuate renal damage and improve long term patient outcomes. In this review article we outline considerations for future clinical studies of exercise in the AKI population.

History

Citation

BMC Nephrol 21, 446 (2020). https://doi.org/10.1186/s12882-020-02098-9

Author affiliation

Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

BMC nephrology

Volume

21

Issue

1

Pagination

446

Publisher

Springer Science and Business Media LLC

issn

1471-2369

eissn

1471-2369

Acceptance date

09/10/2020

Copyright date

2020

Available date

23/10/2020

Spatial coverage

England

Language

eng