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Extrathoracic muscle wasting in exacerbations of COPD: No longer outside the region of interest

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journal contribution
posted on 16.04.2021, 11:08 by NJ Greening, MI Polkey, HJC McAuley
While airflow limitation is used to diagnose chronic obstructive pulmonary disease (COPD), it is well established that forced expiratory volume in one second alone relates poorly to mortality1 or health-related quality of life.2 Skeletal muscle dysfunction has been shown to be a better predictor than lung function for both prognosis3 and risk of hospitalisation.4 Moreover, skeletal muscle weakness is increasingly recognised as an important component of both frailty and sarcopaenia. Acute exacerbations of COPD (AECOPD) are a feature of many patients with COPD, with intermittent worsening of symptoms contrasting to many other chronic conditions. The impact of exacerbations is well established, with prevention and treatment an important goal for therapy with COPD. [Opening paragraph]

History

Author affiliation

Department of Respiratory Sciences, University of Leicester

Version

AM (Accepted Manuscript)

Published in

Thorax

Publisher

BMJ Publishing Group

issn

0040-6376

eissn

1468-3296

Acceptance date

20/01/2021

Copyright date

2021

Available date

16/04/2021

Spatial coverage

England

Language

English