Feasibility of progesterone treatment for ischaemic stroke.pdf (221.29 kB)
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Feasibility of progesterone treatment for ischaemic stroke

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journal contribution
posted on 12.07.2017, 12:22 by Claire L. Gibson, Philip M. Bath
Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts on the translational potential of progesterone treatment for ischaemic stroke. A wealth of experimental evidence supports the neuroprotective properties of progesterone, and associated metabolites, following various types of central nervous system injury. In particular, for ischaemic stroke, studies have also begun to reveal possible mechanisms of such neuroprotection. However, the results in traumatic brain injury now question whether further clinical development of progesterone for ischaemic stroke is relevant.

History

Citation

Journal of Cerebral Blood Flow and Metabolism, 2016, 36 (3), pp. 487-491

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

Journal of Cerebral Blood Flow and Metabolism

Publisher

SAGE Publications

issn

0271-678X

eissn

1559-7016

Acceptance date

11/07/2015

Copyright date

2015

Available date

12/07/2017

Publisher version

http://journals.sagepub.com/doi/10.1177/0271678X15616782

Language

en