Future options of anti-angiogenic cancer therapy..pdf (1.65 MB)
Download file

Future options of anti-angiogenic cancer therapy.

Download (1.65 MB)
journal contribution
posted on 20.04.2016, 09:30 by Yihai Cao
In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the addition of an anti-angiogenic component to conventional therapeutic modalities has generally produced modest survival benefits for cancer patients. Currently, it is unclear why these clinically available drugs targeting the same angiogenic pathways produce dissimilar effects in preclinical models and human patients. In this article, we discuss possible mechanisms of various anti-angiogenic drugs and the future development of optimized treatment regimens.

History

Citation

Chinese Journal of Cancer, 2016, 35 (1), 21

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

Chinese Journal of Cancer

Publisher

BioMed Central

issn

1000-467X

eissn

1944-446X

Acceptance date

18/01/2016

Copyright date

2016

Available date

20/04/2016

Publisher version

http://cjcjournal.biomedcentral.com/articles/10.1186/s40880-016-0084-4

Language

en