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High-Sensitivity Cardiac Troponin and New-Onset Heart Failure: Could a Quantitative Meta-Analysis Be Performed for the C Index?

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journal contribution
posted on 14.03.2019, 12:57 by TH Cao
I have read the article by Evans and colleagues published in the JACC – Heart Failure with a great interest. The authors conducted a systematic review and meta-analysis of 67,063 patients with 4,165 incident heart failure events from 16 prospective studies. The results in this study suggest that serum high-sensitivity cardiac Troponin is strongly associated with the risk for incident heart failure beyond conventional risk factors. Certainly, Evans et al. have conducted a very valuable and exciting study. However, the authors mentioned that they were not able to perform a quantitative meta-analysis of the C index data in this study because some studies did not report confidence intervals (CI) for C indexes and their changes. Could the authors calculate a quantitative meta-analysis of the C index only using fully reported studies? This would provide a clearer view that many readers might be interested.

Funding

Dr. Cao is funded by the John and Lucille van Geest Foundation and the National Institute for Health Research Leicester Biomedical Research Centre.

History

Citation

JACC Heart Fail, 2018, 6 (6), pp. 540-541

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

JACC Heart Fail

Publisher

Elsevier

eissn

2213-1787

Acceptance date

13/03/2018

Copyright date

2018

Available date

01/06/2019

Publisher version

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2213177918302208?returnurl=https://linkinghub.elsevier.com/retrieve/pii/S2213177918302208?showall=true&referrer=

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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