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Human Group 2 innate lymphoid cells do not express the IL-5 receptor

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journal contribution
posted on 16.05.2017, 08:58 by Adam K. A. Wright, Cathryn Weston, Batika M. J. Rana, Christopher E. Brightling, David J. Cousins
Group 2 innate lymphoid cells (ILC2s) are upstream regulators of IL-5-dependent eosinophil function in asthma. We’ve shown that ILC2s do not express the IL-5R and thus IL-5R- dependent therapeutic interventions (e.g. Benralizumab) are unlikely to be mediated directly on ILC2s.

Funding

This work was part funded by (for CEB) Airway Disease Predicting Outcomes through Patient Specific Computational Modelling (AirPROM) project (funded through FP7 EU grant), Wellcome Senior Fellowship, (for DJC) Medical Research Council (MRC) and Asthma UK (Centre Grant: G1000758), from the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, an equipment grant from the Midlands Asthma and Allergy Research Association (MAARA) and (for CEB and DJC) the National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Unit. BMJR was funded by an MRC and Asthma UK PhD studentship. This paper presents independent research funded by the NIHR.

History

Citation

Journal of Allergy and Clinical Immunology, 2017

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Journal of Allergy and Clinical Immunology

Publisher

Elsevier for American Academy of Allergy, Asthma and Immunology

issn

0091-6749;1097-6825

Acceptance date

12/04/2017

Copyright date

2017

Available date

16/05/2017

Publisher version

http://www.sciencedirect.com/science/article/pii/S0091674917307492

Language

en

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