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Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies

journal contribution
posted on 28.02.2017, 12:35 by Shutan Liao, Mark H. Vickers, Rennae S. Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M. E. McCowan, Philip N. Baker, Jo K. Perry
To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA. We found that maternal serum GH-V concentrations at 20 weeks of gestation in LGA pregnancies were significantly higher than in AGA and SGA pregnancies. Maternal GH-V concentrations were positively correlated to birth weights and customized birth weight centiles, while IGFBP-1 concentrations were inversely related to birth weights and customized birth weight centiles. Our findings suggest that maternal serum GH-V and IGFBP-1 concentrations at 20 weeks' gestation are associated with fetal growth.

History

Citation

Growth Factors, 2016, 34 (5-6), pp. 203-209

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY

Version

AM (Accepted Manuscript)

Published in

Growth Factors

Publisher

Taylor & Francis

issn

0897-7194

eissn

1029-2292

Acceptance date

30/11/2016

Copyright date

2017

Available date

25/01/2018

Publisher version

http://www.tandfonline.com/doi/full/10.1080/08977194.2016.1273223

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en