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Impact of acute choline loading on circulating trimethylamine N-oxide levels.

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journal contribution
posted on 17.04.2019, 12:42 by S Cassambai, A Salzano, Y Yazaki, D Bernieh, M Wong, MZ Israr, LM Heaney, T Suzuki
Despite recent efforts to reduce cardiovascular disease risk by dietary intervention,1few markers are useful to assess the efficiency and progress of this. Circulating levels of trimethylamine N-oxide (TMAO) are associated with poor outcomes of cardiovascular disease.2–6TMAO is generated via hepatic flavin monooxygenase 3 (FMO3) mediated oxidation of trimethylamine (TMA),7derived largely from carnitine and choline through gut microbial metabolism. These substrates are found in red meat and eggs, which are representative of a Western diet. Therefore, TMAO levels could be used to monitor the effect of dietary intervention, particularly for the consumption of a Western diet. In this study, we examined the effect of acute choline loading on TMAO levels in healthy adult volunteers.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: TS receives grant support from the Leicester Drug Discovery and Diagnostics (LD3) MRC Confidence in Concept (CiC) award in collaboration with ADM Protexin Ltd (formerly Probiotics International Ltd).

History

Citation

European Journal of Preventive Cardiology, 2019

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

European Journal of Preventive Cardiology

Publisher

SAGE Publications (UK and US), European Society of Cardiology, European Association for Cardiovascular Prevention and Rehabilitation

eissn

2047-4881

Acceptance date

26/01/2019

Copyright date

2019

Available date

17/04/2019

Publisher version

https://journals.sagepub.com/doi/10.1177/2047487319831372

Language

en

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