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Impact of maternal gestational weight gain in twin pregnancies on early childhood obesity risk: A longitudinal birth cohort study

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journal contribution
posted on 20.09.2022, 10:38 authored by Sisi Li, Yuhan Qiu, Xi Yuan, Qin Zhang, Mark D Kilby, Richard Saffery, Philip N Baker, Li Wen, Chao Tong, Hongbo Qi

Objectives

To investigate the impact of gestational weight gain (GWG) on the body mass index-for-age z score (BAZ) and obesity risk among twin offspring.

Methods

This study included 263 women who were pregnant with twins and their offspring. Maternal GWG was measured in each trimester, and infant weight and length were measured at 6, 12, and 24 months.

Results

Total GWG was positively correlated with offspring birthweight and BAZ at 6, 12 and 24 months [adjusted β 0.013 (95% CI: 0.008-0.019), 0.028 (95% CI: 0.005-0.050), 0.033 (95% CI: 0.010-0.056) and 0.025 (95% CI: 0.004-0.047), respectively]. Excessive total GWG was related to an increased relative risk (RR) of large for gestational age (LGA) and overweight at 6 and 12 months. Only the second trimester gestational weight gain rate (GWGR) was positively correlated with birthweight (adjusted β 0.380, 95% CI: 0.256-0.504), and RRs of 6.818 (95% CI: 1.568-29.642) and 2.852 (95% CI: 1.466-5.548) were found for LGA and overweight at 12 months, respectively.

Conclusions

Total GWG and the second trimester GWGR were correlated with BAZ and overweight/obesity risk in twin offspring; the impact was obvious in the first year of life and gradually disappeared over time.

Clinical trial registration

ChiCTR-OOC-16008203, Registered on 1 April 2016 at the Chinese Clinical Trial Registry.

Funding

This research was supported by the National Natural Science Foundation of China (U21A20346, 81520108013, 82001580, and 82171662), Chongqing Science and Technology Commission (cstc2021ycjh-bgzxm0192), Chongqing Health Committee (2019GDRC012), and Chongqing Education Commission (KJZD-K202100404)

History

Author affiliation

College of Life Sciences, University of Leicester

Version

VoR (Version of Record)

Published in

FRONTIERS IN PEDIATRICS

Volume

10

Publisher

FRONTIERS MEDIA SA

issn

2296-2360

eissn

2296-2360

Copyright date

2022

Available date

20/09/2022

Spatial coverage

Switzerland

Language

English