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In Vivo Foveal Development Using Optical Coherence Tomography

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posted on 29.05.2015, 15:22 by H. Lee, R. Purohit, A. Patel, E. Papageorgiou, V. Sheth, G. Maconachie, A. Pilat, R. McLean, Frank A. Proudlock, Irene Gottlob
Purpose: To characterize the time course of normal foveal development in vivo in term infants and young children using handheld spectral-domain optical coherence tomography (HH-SDOCT). Methods: We obtained 534 HH-SDOCT scans from 261 infants, children, and young adults with a mean age of 4.9 years (range, 0–27 years). Each retinal layer was manually segmented in ImageJ and correlated with gestational age (GA) and visual acuity (VA). The developmental trajectories of each retinal layer at the fovea, parafovea, and perifovea were calculated using fractional polynomial modeling. Results: The central macular thickness (CMT) increases logarithmically between birth and 48.6 months GA. The foveal ganglion cell (GCL), inner plexiform, inner nuclear (INL), and outer plexiform layers decrease in thickness exponentially until 18 months GA. Interestingly, the parafoveal and perifoveal GCL and INL thicknesses initially decrease until 17 months GA and then increase in thickness until 65.5 GA. The foveal outer nuclear layer, inner segment, and outer segment of the photoreceptors increase in thickness logarithmically until 32.4, 26.9, and 45.3 months GA, respectively. The parafoveal and perifoveal outer retinal layers increase in thickness more gradually until 146 months GA. The thickness of the outer retinal layers and CMT were strongly correlated with VA, with r = 0.54 (P < 0.0001) and r = 0.52 (P < 0.0001), respectively. Conclusions: We have modeled for the first time the complex, nonlinear developmental trajectories for each retinal layer and demonstrate that development continues until adolescence. Our description of normal development will be helpful in diagnosing, monitoring, and understanding pediatric retinal disease.

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Citation

Investigative Ophthalmology & Visual Science July 2015, Vol.56, 4537-4545.

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

Investigative Ophthalmology & Visual Science July 2015

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

issn

0146-0404

eissn

1552-5783

Available date

07/01/2017

Publisher version

http://iovs.arvojournals.org/article.aspx?articleid=2398224

Editors

Yorio, T

Language

en

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