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Inflammatory factors and exercise in chronic kidney disease.

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journal contribution
posted on 05.03.2015, 11:57 by Maurice Dungey, Katherine L. Hull, Alice C. Smith, James O. Burton, Nicolette C. Bishop
Patients with chronic kidney disease frequently present with chronic elevations in markers of inflammation, a condition that appears to be exacerbated by disease progression and onset of haemodialysis. Systemic inflammation is interlinked with malnutrition and muscle protein wasting and is implicated in a number of morbidities including cardiovascular disease: the most common cause of mortality in this population. Research in the general population and other chronic disease cohorts suggests that an increase in habitual activity levels over a prolonged period may help redress basal increases in systemic inflammation. Furthermore, those populations with the highest baseline levels of systemic inflammation appear to have the greatest improvements from training. On the whole, the activity levels of the chronic kidney disease population reflect a sedentary lifestyle, indicating the potential for increasing physical activity and observing health benefits. This review explores the current literature investigating exercise and inflammatory factors in the chronic kidney disease population and then attempts to explain the contradictory findings and suggests where future research is required.

History

Citation

International Journal of Endocrinology Volume 2013 (2013), Article ID 569831, 12 pages

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

International Journal of Endocrinology Volume 2013 (2013)

Publisher

Hindawi Publishing Corporation

issn

1687-8337

eissn

1687-8345

Copyright date

2013

Available date

05/03/2015

Publisher version

http://www.hindawi.com/journals/ije/2013/569831/

Notes

PMCID: PMC3666228

Language

en

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