File(s) under permanent embargo

Reason: This item is currently closed access.

Innate Lymphoid Cells

journal contribution
posted on 28.10.2015, 16:28 by David J. Cousins, Cathryn Weston
Innate lymphoid cells (ILCs) are white blood cells derived from a common progenitor in the bone marrow . They respond rapidly to a limited array of antigens at the site of infection to provide immediate protection . The first identified ILCs were natural killer cells. H owever, several non - cytotoxic members of the family have since been reported. All ILCs lack the rearranged antigen - receptors characteristic of T - and B - cells but can be similarly divided into three main groups based on cell surface markers and cytokine expression profiles. Like their adaptive immune response counterparts they play specific roles in p roviding host defence against different pathogens. In addition, there is growing evidence that ILCs can contribute to multiple inflammatory and auto immune diseases.

History

Citation

eLS, 2015, (In press)

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

eLS

Publisher

Wiley

isbn

9780470015902

Acceptance date

19/08/2015

Copyright date

1999

Publisher version

http://onlinelibrary.wiley.com/book/10.1002/047001590X/

Language

en

Usage metrics

Categories

Keywords

Exports