Intracerebral hemorrhage location and outcome among INTERACT2 participants.pdf (388.15 kB)
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Intracerebral hemorrhage location and outcome among INTERACT2 participants

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posted on 15.05.2017, 14:45 by Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, Xiaoying Chen, Maree L Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Thompson Robinson, Leo Davies, Pablo M. Lavados, Richard I. Lindley, Christian Stapf, John Chalmers, Craig S. Anderson, INTERACT2 Investigators
OBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). CONCLUSION: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. CLINICALTRIALSGOV REGISTRATION: NCT00716079.

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Citation

Neurology, 2017, 88 (15), pp. 1408-1414

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

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VoR (Version of Record)

Published in

Neurology

Publisher

American Academy of Neurology (AAN)

issn

0028-3878

eissn

1526-632X

Acceptance date

18/01/2017

Copyright date

2017

Available date

15/05/2017

Publisher version

http://www.neurology.org/content/88/15/1408

Language

en

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