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Invited Topical Review: Acid-base balance and cerebrovascular regulation

journal contribution
posted on 25.11.2021, 16:21 by Jatinder Minhas, Hannah Caldwell, Jay Carr, Erik Swenson, Philip Ainslie
The regulation and defense of intracellular pH is essential for homeostasis. Indeed, alterations in cerebrovascular acid-base balance directly affect cerebral blood flow (CBF) which has implications for human health and disease. For example, changes in CBF regulation during acid-base disturbances are evident in conditions such as chronic obstructive pulmonary disease and diabetic ketoacidosis. The classic experimental studies from the past 75+ years are utilized to describe the integrative relationships between CBF, carbon dioxide tension (PCO2), bicarbonate (HCO3–), and pH. These factors interact to influence 1) the time course of acid-base compensatory changes and the respective cerebrovascular responses (due to rapid exchange kinetics between arterial, extracellular fluid, and intracellular brain tissue). We propose that alterations in arterial [HCO3–] during acute respiratory acidosis/alkalosis contribute to cerebrovascular acid-base regulation; and 2) the regulation of CBF by direct changes in arterial versus extravascular/ interstitial PCO2 and pH – the latter recognized as the proximal compartment which alters vascular smooth muscle cell regulation of CBF. Taken together, these results substantiate two key ideas: first, that the regulation of CBF is affected by the severity of metabolic/respiratory disturbances, including the extent of partial/full acid-base compensation. Second, that the regulation of CBF is independent of arterial pH and that diffusion of CO2 across the blood-brain barrier is integral to altering perivascular extracellular pH. Overall, by realizing the integrative relationships between CBF, PCO2, HCO3–, and pH, experimental studies may provide insights to improve CBF regulation in clinical practice with treatment of systemic acid-base disorders.

History

Citation

The Journal of Physiology, https://doi.org/10.1113/JP281517

Author affiliation

NIHR Leicester Biomedical Research Centre, Department of Cardiovascular Sciences,

Version

AM (Accepted Manuscript)

Published in

The Journal of Physiology

Publisher

Wiley

issn

0022-3751

eissn

1469-7793

Acceptance date

19/10/2021

Copyright date

2021

Available date

27/10/2022

Language

en