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Lack of correlation between metastasis of human rectal carcinoma and the absence of stromal fibronectin

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posted on 09.12.2016, 11:51 by P. Niemczuk, R. M. Perkins, I. C. Talbot, D. R. Critchley
In a retrospective study we have used an immunoperoxidase procedure to localize the glycoprotein fibronectin in human rectal carcinomas, concentrating on tumour invading thick-walled extramural veins. Fibronectin was present in 29 out of 38 cases, in connective tissue stroma, and was not in direct association with the tumour cells, except in areas of necrosis. We found no correlation between the presence or absence of stromal fibronectin and (1) the degree of cellular differentiation within the tumour, (2) tumour progression (Dukes' classification) (3) the subsequent development of metastases and (4) patient longevity. OUr results do not support the conclusions from in vitro studies (Smith et al., 1979) that the metastatic potential of carcinomas may be partly determined by the ability of tumour cells to synthesize pericellular fibronectin.

History

Citation

British Journal of Cancer (1982) 45, 500–505.

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Molecular & Cell Biology

Version

VoR (Version of Record)

Published in

British Journal of Cancer (1982) 45

Publisher

Cancer Research UK, Nature Publishing Group

issn

0007-0920

eissn

1532-1827

Acceptance date

15/12/1981

Available date

09/12/2016

Publisher version

http://www.nature.com/bjc/journal/v45/n4/abs/bjc198285a.html

Language

en

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