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Leisure-time Physical Activity and Life Expectancy in people with Cardiometabolic Multimorbidity and Depression.

journal contribution
posted on 17.10.2019, 16:18 by Yogini V. Chudasama, Francesco Zaccardi, Clare L. Gillies, Nafeesa N. Dhalwani, Thomas Yates, Alex V. Rowlands, Melanie J. Davies, Kamlesh K. Khunti
BACKGROUND: Whether and to what extent leisure-time physical activity at the recommended levels of 150 minutes moderate activity is associated with survival in people with cardiometabolic multimorbidity and depression is unknown. METHODS: UK Biobank participants were classified into groups: (1) no disease; (2) diabetes; (3) cardiovascular disease (CVD); (4) depression; (5) diabetes and CVD; (6) diabetes and depression; (7) CVD and depression; (8) diabetes, CVD and depression. Leisure-time physical activity was categorised as active (meeting recommendations) or inactive. Survival models were applied to estimate life expectancy. RESULTS: 480,940 participants were included (median age, 58 years; 46% men; 95% white), of whom 74% with cardiometabolic multimorbidity and depression were inactive. During a mean follow-up of 7 years, 11006 deaths occurred. At age of 45 years, being physically active was associated with 2.34 (95% confidence interval: 0.93, 3.54) additional years of life compared to being inactive in participants with diabetes; corresponding estimate were 2.28 (1.40, 3.16) for CVD; 2.15 (0.05, 4.26) for diabetes and CVD; and 1.58 (1.27, 1.89) for no disease. Participants with a combination of diabetes, CVD and depression, being active was associated with 6.81 (-1.50, 15.31) additional years compared to being inactive; corresponding estimates were 3.07 (-2.46, 8.59) for diabetes and depression; 2.34 (-1.24, 5.91) for CVD and depression; and 0.80 (-0.46, 2.05) for depression. A similar pattern was found at 65 years. CONCLUSIONS: Meeting the recommended level of physical activity was associated with a longer life expectancy in people with cardiometabolic multimorbidity but not in those with depression.


YC is funded by a University of Leicester College of Medicine, Biological Sciences and Psychology PhD studentship in collaboration with Collaboration for Leadership in Applied Health Research and Care East Midlands.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.



Journal of Internal Medicine, 2019

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/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre


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Journal of Internal Medicine





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The data that support the findings of this study are available from UK Biobank project site, subject to registration and application process. Further details can be found at https://www.ukbiobank.ac.uk. Statistical codes for this study are available at GitHub yc244.;The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.