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Long-lasting deficits in hedonic and nucleus accumbens reactivity to sweet rewards by sugar overconsumption during adolescence

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journal contribution
posted on 17.04.2020, 08:59 by Fabien Naneix, Florence Darlot, Etienne Coutureau, Martine Cador
Adolescence is a critical period characterized by major neurobiological changes. Chronic stimulation of the reward system might constitute an important factor in vulnerability to pathological development. In spite of the dramatic increase in the consumption of sweet palatable foods during adolescence in our modern societies, the long-term consequences of such exposure on brain reward processing remain poorly understood. Here, we investigated in rats the long-lasting effects of sugar overconsumption during their adolescence on their adult reactivity to the hedonic properties of sweet rewards. Adolescent rats with continuous access to 5% sucrose solution (from postnatal day 30-46) showed escalating intake. At adulthood (post-natal day 70), using two-bottle free choice tests, sucrose-exposed rats showed lower intake than non-exposed rats suggesting decreased sensitivity to the rewarding properties of sucrose. In Experiment 1, we tested their hedonic-related orofacial reactions to intraoral infusion of tasty solutions. We showed that sucrose-exposed rats presented less hedonic reactions in response to sweet tastes leaving the reactivity to water or quinine unaltered. Hence, in Experiment 2, we observed that this hedonic deficit is associated with lower c-Fos expression levels in the nucleus accumbens, a brain region known to play a central role in hedonic processing. These findings demonstrate that a history of high sucrose intake during the critical period of adolescence induces long-lasting deficits in hedonic treatment that may contribute to reward-related disorders.

Funding

This work is supported by the CNRS, the Conseil Régional d'Aquitaine and the FondFrançais Alimentation Santé (grant no. C11022). F.N. is supported by the Fond FrançaisAlimentation Santé. We thank Mariangela Martini and Sophie Pillon for their assistance in theimplementation of the taste reactivity paradigm, Gilles Courtand, Angélique Faugère, andYoan Salafranque for technical help and Dr Shauna L. Parkes for her helpful discussions andcomments on the manuscript. The microscopy was done in the Bordeaux Imaging Centre, aservice unit of the CNRS-INSERM and Bordeaux University, member of the FranceBioImaging national infrastructure, with help from Christelle Poujol and Sébastien Marais.

History

Citation

Naneix, F., Darlot, F., Coutureau, E. and Cador, M. (2016), Long‐lasting deficits in hedonic and nucleus accumbens reactivity to sweet rewards by sugar overconsumption during adolescence. Eur J Neurosci, 43: 671-680. doi:10.1111/ejn.13149

Version

AM (Accepted Manuscript)

Published in

EUROPEAN JOURNAL OF NEUROSCIENCE

Volume

43

Issue

5

Pagination

671 - 680 (10)

Publisher

WILEY

issn

0953-816X

eissn

1460-9568

Acceptance date

17/11/2015

Copyright date

2016

Available date

13/01/2016

Publisher version

https://onlinelibrary.wiley.com/doi/full/10.1111/ejn.13149

Spatial coverage

France

Language

English