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Long-term exposure to air pollution and liver cancer incidence in six European cohorts

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journal contribution
posted on 04.10.2021, 16:16 by Rina So, Jie Chen, Amar J Mehta, Shuo Liu, Maciej Strak, Kathrin Wolf, Ulla A Hvidtfeldt, Sophia Rodopoulou, Massimo Stafoggia, Jochem O Klompmaker, Evangelia Samoli, Ole Raaschou-Nielsen, Richard Atkinson, Mariska Bauwelinck, Tom Bellander, Marie-Christine Boutron-Ruault, Jorgen Brandt, Bert Brunekreef, Giulia Cesaroni, Hans Concin, Francesco Forastiere, Carla H van Gils, John Gulliver, Ole Hertel, Barbara Hoffmann, Kees de Hoogh, Nicole Janssen, Youn-Hee Lim, Rudi Westendorp, Jeanette T Jorgensen, Klea Katsouyanni, Matthias Ketzel, Anton Lager, Alois Lang, Petter L Ljungman, Patrik KE Magnusson, Gabriele Nagel, Mette K Simonsen, Goran Pershagen, Raphael S Peter, Annette Peters, Matteo Renzi, Debora Rizzuto, Torben Sigsgaard, Danielle Vienneau, Gudrun Weinmayr, Gianluca Severi, Daniela Fecht, Anne Tjonneland, Karin Leander, Gerard Hoek, Zorana J Andersen
Particulate matter air pollution and diesel engine exhaust have been classified as carcinogenic for lung cancer, yet few studies have explored associations with liver cancer. We used six European adult cohorts which were recruited between 1985 and 2005, pooled within the “Effects of low-level air pollution: A study in Europe” (ELAPSE) project, and followed for the incidence of liver cancer until 2011 to 2015. The annual average exposure to nitrogen dioxide (NO2), particulate matter with diameter <2.5 μm (PM2.5), black carbon (BC), warm-season ozone (O3), and eight elemental components of PM2.5 (copper, iron, zinc, sulfur, nickel, vanadium, silicon, and potassium) were estimated by European-wide hybrid land-use regression models at participants' residential addresses. We analyzed the association between air pollution and liver cancer incidence by Cox proportional hazards models adjusting for potential confounders. Of 330 064 cancer-free adults at baseline, 512 developed liver cancer during a mean follow-up of 18.1 years. We observed positive linear associations between NO2 (hazard ratio, 95% confidence interval: 1.17, 1.02-1.35 per 10 μg/m3), PM2.5 (1.12, 0.92-1.36 per 5 μg/m3), and BC (1.15, 1.00-1.33 per 0.5 10−5/m) and liver cancer incidence. Associations with NO2 and BC persisted in two-pollutant models with PM2.5. Most components of PM2.5 were associated with the risk of liver cancer, with the strongest associations for sulfur and vanadium, which were robust to adjustment for PM2.5 or NO2. Our study suggests that ambient air pollution may increase the risk of liver cancer, even at concentrations below current EU standards.

Funding

Health Effects Institute Research Agreement, Grant/Award Number: 4954-RFA14-3/16-5-3;

Novo Nordisk Foundation Challenge Programme, Grant/Award Number: NNF17OC0027812

History

Author affiliation

Department of Health Sciences, University of Leicester

Version

VoR (Version of Record)

Published in

International Journal of Cancer

Publisher

Wiley

issn

0020-7136

eissn

1097-0215

Acceptance date

16/06/2021

Copyright date

2021

Available date

04/10/2021

Spatial coverage

United States

Language

English