MIRATE: MIps RATional dEsign Science Gateway.pdf (764.56 kB)
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MIRATE: MIps RATional dEsign Science Gateway.

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journal contribution
posted on 24.09.2019, 12:59 by M Busato, R Distefano, F Bates, K Karim, AM Bossi, JM López Vilariño, S Piletsky, N Bombieri, A Giorgetti
Molecularly imprinted polymers (MIPs) are high affinity robust synthetic receptors, which can be optimally synthesized and manufactured more economically than their biological equivalents (i.e. antibody). In MIPs production, rational design based on molecular modeling is a commonly employed technique. This mostly aids in (i) virtual screening of functional monomers (FMs), (ii) optimization of monomer-template ratio, and (iii) selectivity analysis. We present MIRATE, an integrated science gateway for the intelligent design of MIPs. By combining and adapting multiple state-of-the-art bioinformatics tools into automated and innovative pipelines, MIRATE guides the user through the entire process of MIPs' design. The platform allows the user to fully customize each stage involved in the MIPs' design, with the main goal to support the synthesis in the wet-laboratory. AVAILABILITY: MIRATE is freely accessible with no login requirement at http://mirate.di.univr.it/. All major browsers are supported.

History

Citation

Journal of Integrative Bioinformatics, 2018, 15(4)

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry

Version

VoR (Version of Record)

Published in

Journal of Integrative Bioinformatics

Publisher

De Gruyter

eissn

1613-4516

Acceptance date

09/04/2018

Copyright date

2018

Available date

24/09/2019

Publisher version

https://www.degruyter.com/view/j/jib.2018.15.issue-4/jib-2017-0075/jib-2017-0075.xml

Notes

The online version of this article offers supplementary material (DOI:https://doi.org/10.1515/jib-2017-0075)

Language

en

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