Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment.pdf (305.55 kB)
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Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment.

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journal contribution
posted on 25.07.2019, 12:55 by NA Fineberg, AM Apergis-Schoute, MM Vaghi, P Banca, CM Gillan, V Voon, SR Chamberlain, E Cinosi, J Reid, S Shahper, ET Bullmore, BJ Sahakian, TW Robbins
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder, distributed network perturbation appears focused around the prefrontal cortex, caudate, putamen, and associated neuro-circuitry. Obsessive compulsive disorder-related attentional set-shifting deficits correlated with reduced resting state functional connectivity between the dorsal caudate and the ventrolateral prefrontal cortex on neuroimaging. In contrast, experimental provocation of obsessive compulsive disorder symptoms reduced neural activation in brain regions implicated in goal-directed behavioral control (ventromedial prefrontal cortex, caudate) with concordant increased activation in regions implicated in habit learning (presupplementary motor area, putamen). The ventromedial prefrontal cortex plays a multifaceted role, integrating affective evaluative processes, flexible behavior, and fear learning. Findings from a neuroimaging study of Pavlovian fear reversal, in which obsessive compulsive disorder patients failed to flexibly update fear responses despite normal initial fear conditioning, suggest there is an absence of ventromedial prefrontal cortex safety signaling in obsessive compulsive disorder, which potentially undermines explicit contingency knowledge and may help to explain the link between cognitive inflexibility, fear, and anxiety processing in compulsive disorders such as obsessive compulsive disorder.

Funding

T.W.R. and colleagues (A.A.-S., P.B.) acknowledge financial support for studies on OCD from the Wellcome Trust (grant 104631/Z/14/Z). M.M.V. is supported by a Pinsent-Darwin Studentship in Mental Pathology and a Cambridge Home and European Union Scholarship Scheme studentship. C.M.G. is supported by a fellowship from MQ. Dr Chamberlain’s involvement in this work was funded by a Wellcome Trust Fellowship (110049/Z/15/Z).

History

Citation

International Journal of Neuropsychopharmacology, 2018, 21 (1), pp. 42-58

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

International Journal of Neuropsychopharmacology

Publisher

Oxford University Press (OUP) for Collegium Internationale Neuro-Psychopharmacologicum

eissn

1469-5111

Acceptance date

18/09/2017

Copyright date

2017

Available date

25/07/2019

Publisher version

https://academic.oup.com/ijnp/article/21/1/42/4210641

Language

en

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