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Maternal serum IGF-1, IGFBP-1 and 3, and placental growth hormone at 20 weeks' gestation in pregnancies complicated by preeclampsia

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journal contribution
posted on 08.04.2020, 08:56 by Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley ME McCowan, Philip N Baker, Jo K Perry
Objective To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). Study design In a nested case-control study, PE cases (n = 71) and matched controls (n = 71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20 weeks of gestation were determined by ELISA. Results We found that maternal serum GH-V concentration at 20 weeks of gestation was unaltered in the PE group, compared to the control group (median, 1.78 ng/ml vs. 1.65 ng/ml, p = 0.884). Maternal IGF-1 and IGFBP-3 concentrations and the IGF-1/IGFBP-3 ratio in PE pregnancies were significantly higher than in controls (median, 253.1 ng/ml vs. 204.3 ng/ml, p < 0.0001; 8535 ng/ml vs. 7711 ng/ml, p = 0.0023; 0.032 vs. 0.026, p < 0.0001, respectively), whereas maternal IGFBP-1 concentration was significantly lower in PE pregnancies than in controls (median, 34.85 ng/ml vs. 48.92 ng/ml, p = 0.0006). Conclusion Our findings suggest a potential role of IGFs and IGFBPs in the prediction of pregnancies complicated by PE. However, the maternal serum concentration of GH-V at 20 weeks’ gestation is unlikely to be useful in the early prediction of PE.

Funding

The New Zealand SCOPE study was funded by the New Enterprise Research Fund, Foundation for Research Science and Technology; Health Research Council (04/198); Evelyn Bond Fund, Auckland District Health Board Charitable Trust. This work was funded by The Maurice and Phyllis Paykel Trust and Gravida: National Centre for Growth and Development.

History

Citation

Pregnancy Hypertension Volume 10, October 2017, Pages 149-154

Version

AM (Accepted Manuscript)

Published in

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

Volume

10

Pagination

149 - 154 (6)

Publisher

ELSEVIER SCI LTD

issn

2210-7789

eissn

2210-7797

Acceptance date

25/07/2017

Copyright date

2017

Available date

27/07/2017

Publisher version

https://www.sciencedirect.com/science/article/pii/S2210778917300697

Spatial coverage

Netherlands

Language

English