Yant_CB_REVISED_20130817.pdf (333.18 kB)
Download file

Meiotic adaptation to genome duplication in Arabidopsis arenosa

Download (333.18 kB)
journal contribution
posted on 02.02.2015, 12:36 by L. Yant, J. D. Hollister, K. M. Wright, B. J. Arnold, James D. Higgins, F. Chris H. Franklin, K. Bomblies
Whole genome duplication (WGD) is a major factor in the evolution of multicellular eukaryotes, yet by doubling the number of homologs, WGD severely challenges reliable chromosome segregation, a process conserved across kingdoms. Despite this, numerous genome-duplicated (polyploid) species persist in nature, indicating early prob- lems can be overcome. Little is known about which genes are involved—only one has been molecularly charac- terized. To gain new insights into the molecular basis of adaptation to polyploidy, we investigated genome-wide patterns of differentiation between natural diploids and tetraploids of Arabidopsis arenosa, an outcrossing relative of A. thaliana. We first show that diploids are not preadapted to polyploid meiosis. We then use a genome scanning approach to show that although polymorphism is extensively shared across ploidy levels, there is strong ploidy-specific differentiation in 39 regions spanning 44 genes. These are discrete, mostly single-gene peaks of sharply elevated differentiation. Among these peaks are eight meiosis genes whose encoded proteins coordinate a specific subset of early meiotic functions, suggesting these genes comprise a polygenic solution to WGD-associated chromosome segregation challenges. Our findings indicate that even conserved meiotic processes can be capable of nimble evolutionary shifts when required.

History

Citation

Current Biology, 2013, 23, pp. 2151-2156 (6)

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Biology

Version

AM (Accepted Manuscript)

Published in

Current Biology

Publisher

Elsevier (Cell Press)

issn

0960-9822

eissn

1879-0445

Available date

02/02/2015

Publisher version

http://www.sciencedirect.com/science/article/pii/S0960982213011251

Notes

Supplemental Information includes Supplemental Experimental Procedures and six tables and can be found with this article online at http://dx.doi.org/ 10.1016/j.cub.2013.08.059

Language

en

Usage metrics

Categories

Keywords

Exports