BPS-D-18-01810 (3).pdf (414.41 kB)
Microglia, Monocytes, and the Recurrence of Anxiety in Stress-Sensitized Mice.
journal contribution
posted on 2019-07-10, 15:34 authored by Golo Kronenberg, Ria Uhlemann, Matthias Endres, Karen GertzTo the Editor:
We read with great interest the article by Weber et al. (1) in Biological Psychiatry describing the effects of microglia elimination and repopulation on stress sensitization induced by repeated social defeat (RSD). The article highlights brain-immune interactions and, in particular, the importance of stress-primed microglia for monocyte accumulation in the brain of RSD-sensitized mice following acute stress. The transcriptomic analysis of microglia 24 days after RSD could be very useful to other researchers, so the authors may wish to make this information accessible to the community by depositing it to an appropriate data repository.
Funding
This work was supported by the Deutsche Forschungsgemeinschaft (Grant Nos. SFB TRR43 and Exc257 [to ME], Grant No. KR 2956/4-1 [to GK], and Grant No. 2576/2-1 [to KG]), Bundesministerium für Bildung und Forschung (Grant No. CSB 01 EO 1301 [to ME, KG, and GK]), German Center for Neurodegenerative Diseases (to ME), German Center for Cardiovascular Research (to ME), and Corona Foundation (to ME).
History
Citation
Biological Psychiatry, 2019, 85 (12), pp. e67-e68Author affiliation
/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular SciencesVersion
- AM (Accepted Manuscript)
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Biological PsychiatryPublisher
Elsevier for Society of Biological Psychiatryeissn
1873-2402Acceptance date
2019-01-30Copyright date
2019Publisher DOI
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https://www.sciencedirect.com/science/article/pii/S0006322319300721?via=ihubNotes
The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.Language
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