Mitochondrial pharmacology turns its sights on the Ca2+ uniporter.pdf (831.73 kB)
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Mitochondrial pharmacology turns its sights on the Ca2+ uniporter

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journal contribution
posted on 27.04.2018, 14:30 by Nina M. Storey, David G. Lambert
Opening paragraph…To use a well-known phrase, mitochondria are the ‘power house of the cell’ and produce ATP, the energetic currency of life.1 Although this is a vital role, mitochondria also have many other crucial roles including cell death pathways such as collapse of the mitochondrial membrane potential by opening the mitochondrial permeability transition pore (mPTP). These roles are profoundly affected by the entry of calcium into the mitochondria. Mitochondrial calcium increases the likelihood of mPTP opening, regulation of metabolic rate by activation of metabolic enzymes (dehydrogenases), reactive oxygen species production, signalling (Ca-calmodulin) and influencing the pattern of global calcium oscillations in response to receptor stimulation.

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Citation

Cell Death Discovery, 2017, 3, 17064

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

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VoR (Version of Record)

Published in

Cell Death Discovery

Publisher

Nature Publishing Group

issn

2058-7716

eissn

2058-7716

Copyright date

2017

Available date

27/04/2018

Publisher version

http://www.nature.com/articles/cddiscovery201764

Language

en

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