BJP commentary_hERG1 activation_accepted_0717.pdf (173.03 kB)
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Modulation of hERG potassium channels by a novel small molecule activator

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journal contribution
posted on 09.05.2018, 12:04 by John S. Mitcheson, Jules C. Hancox
(Opening paragraph) KCNH2-encoded hERG1 channels conduct the rapid delayed rectifier potassium current (IKr), which plays a vital role in controlling the duration of cardiac action potentials. Ever since the importance of hERG1 currents in regulating cardiac repolarisation was first demonstrated there has been considerable interest in pharmacologically manipulating these channels. In this issue, Sale et al. (2017), have characterised the properties of a structurally and functionally novel hERG activator, ITP-2, which dramatically increases hERG1 current amplitudes.

History

Citation

British Journal of Pharmacology, 2017, 174 (20), pp. 3669-3671

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Molecular & Cell Biology

Version

AM (Accepted Manuscript)

Published in

British Journal of Pharmacology

Publisher

Wiley

issn

0007-1188

eissn

1476-5381

Acceptance date

10/07/2017

Copyright date

2017

Available date

09/09/2018

Publisher version

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.13964

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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