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Native lung pneumonectomy for post-transplantation lymphoproliferative disorder refractory to rituximab following contralateral lung transplantation

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posted on 08.04.2020, 13:24 by Marius Roman, Jasvir Parmar, Martin Goddard, Piergiorgio Solli
Post-transplantation lymphoproliferative disorder (PTLD) is a life-threatening complication following lung transplantation. We report a PTLD case of high-grade, B-cell lymphoma following contralateral single-lung transplantation. The disease involved the liver, right kidney and right native lung. While the PTLD affecting the abdominal organs regressed with rituximab chemotherapy, the native lung disease progressed and was treated surgically (right pneumonectomy). Some aspects are unique in this case: (i) different response to medical treatment between lung and abdominal organs; (ii) absolute absence of involvement of the native lung and (iii) surgical treatment with a pneumonectomy, still very rarely described in the literature. We hypothesized that a different morphotype of the disease involved the abdominal organs or the penetrance of rituximab, and chemotherapy could have been impaired by the presence of pulmonary fibrosis.

History

Citation

Marius Roman, Jasvir Parmar, Martin Goddard, Piergiorgio Solli, Native lung pneumonectomy for post-transplantation lymphoproliferative disorder refractory to rituximab following contralateral lung transplantation, Interactive CardioVascular and Thoracic Surgery, Volume 23, Issue 5, November 2016, Pages 841–843, https://doi.org/10.1093/icvts/ivw235

Version

AM (Accepted Manuscript)

Published in

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY

Volume

23

Issue

5

Pagination

841 - 843 (3)

Publisher

OXFORD UNIV PRESS

issn

1569-9293

eissn

1569-9285

Acceptance date

15/06/2016

Copyright date

2016

Available date

15/07/2016

Publisher version

https://academic.oup.com/icvts/article/23/5/841/2399441

Language

English