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Neurochemical measurements in the zebrafish brain

journal contribution
posted on 26.08.2015, 09:04 by William H. J. Norton, Lauren Jones, James E. McCutcheon, Andrew M. J. Young
The zebrafish is an ideal model organism for behavioural genetics and neuroscience. The high conservation of genes and neurotransmitter pathways between zebrafish and other vertebrates permits the translation of research between species. Zebrafish behaviour can be studied at both larval and adult stages and recent research has begun to establish zebrafish models for human disease. Fast scan cyclic voltammetry (FSCV) is an electrochemical technique that permits the detection of neurotransmitter release and reuptake. In this study we have used in vitro FSCV to measure the release of analytes in the adult zebrafish telencephalon. We compare different stimulation methods and present a characterisation of neurochemical changes in the wild-type zebrafish brain. This study represents the first FSCV recordings in zebrafish, thus paving the way for neurochemical analysis of the fish brain.

History

Citation

Frontiers in Behavioral Neuroscience, Sept 2015, 9:246. doi: 10.3389/fnbeh.2015.00246

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Biology

Version

VoR (Version of Record)

Published in

Frontiers in Behavioral Neuroscience

Publisher

Frontiers

issn

1662-5153

Acceptance date

25/08/2015

Copyright date

2015

Available date

26/08/2015

Publisher version

http://journal.frontiersin.org/article/10.3389/fnbeh.2015.00246/abstract

Language

en