Neurovascular coupling response to cognitive examination in healthy controls: a multivariate analysis.pdf (1.21 MB)
Download file

Neurovascular coupling response to cognitive examination in healthy controls: a multivariate analysis.

Download (1.21 MB)
journal contribution
posted on 25.06.2019, 10:05 by L Beishon, CAL Williams, TG Robinson, VJ Haunton, RB Panerai
Cognitive testing with transcranial Doppler ultrasonography (TCD) has been used to assess neurovascular coupling (NVC), but few studies address its multiple contributions. Subcomponent analysis considers the relative myogenic (resistance area product, RAP) and metabolic (critical closing pressure (CrCP)) contributors. The aim of this study was to investigate the changes in subcomponents that occur with cognitive stimulation with the Addenbrooke's Cognitive Examination (ACE-III) in healthy controls. Healthy volunteers underwent continuous recording of bilateral TCD, heart rate (HR, three-lead ECG), end-tidal CO2 (ETCO2 , capnography), and mean arterial pressure (MAP, Finometer). The study comprised a 5-min baseline recording, followed by all 20 paradigms from the ACE-III. The cerebral blood flow velocity (CBFv) response was decomposed into the relative contributions (subcomponents); VBP (MAP), VCrCP (CrCP), and VRAP (RAP). Data are presented as peak population normalized mean changes from baseline, and median area under the curve (AUC). Forty bilateral datasets were obtained (27 female, 37 right hand dominant). VBP increased at task initiation in all paradigms but differed between tasks (range (SD): 4.06 (8.92)-16.04 (12.23) %, P < 0.05). HR, but not ETCO2 , also differed significantly (P < 0.05). Changes in VRAP reflected changes in MAP, but in some paradigms atypical responses were seen. VCrCP AUC varied significantly within paradigm sections (range [SD]: 18.4 [24.17] to 244.21 [243.21] %*s, P < 0.05). All paradigms demonstrated changes in subcomponents with cognitive stimulation, and can be ranked based on their relative presumed metabolic demand. The integrity of NVC requires further investigation in patient populations.


CALW was chosen by the University of Leicester to be supported by the Association of Physicians. The sponsors did not have a direct role in the conduct of the research. TGR is a NIHR Senior Investigator. LB is a NIHR Academic Clinical Fellow.



Physiological Reports, 2018, 6 (14), e13803

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences


VoR (Version of Record)

Published in

Physiological Reports


Wiley, American Physiological Society, Physiological Society



Acceptance date


Copyright date


Available date


Publisher version