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Nociceptin system as a target in sepsis?

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journal contribution
posted on 03.09.2015, 10:15 by Róisín Thomas, Cordula Stover, David G. Lambert, Jonathan P. Thompson
The nociceptin system comprises the nociceptin receptor (NOP) and the ligand nociceptin/orphanin FQ (N/OFQ) that binds to the receptor. The archetypal role of the system is in pain processing but the NOP receptor is also expressed on immune cells. Activation of the NOP receptor is known to modulate inflammatory responses, such as mast-cell degranulation, neutrophil rolling, vasodilation, increased vascular permeability, adhesion molecule regulation and leucocyte recruitment. As there is a loss of regulation of inflammatory responses during sepsis, the nociceptin system could be a target for therapies aimed at modulating sepsis. This review details the known effects of NOP activation on leucocytes and the vascular endothelium and discusses the most recent human and animal data on the role of the nociceptin system in sepsis.

History

Citation

Journal of Anesthesia, 2014, 28 (5), pp. 759-767

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

Journal of Anesthesia

Publisher

Springer-Verlag Tokyo

issn

0913-8668

eissn

1438-8359

Acceptance date

05/03/2014

Copyright date

2014

Available date

01/10/2015

Publisher version

http://link.springer.com/article/10.1007/s00540-014-1818-6

Language

en

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