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Non-targeted metabolomics in sport and exercise science

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journal contribution
posted on 27.03.2017, 10:54 by Liam M. Heaney, Kevin Deighton, Toru Suzuki
Metabolomics incorporates the study of metabolites that are produced and released through physiological processes at both the systemic and cellular level. Biological compounds at the metabolite level are of paramount interest in the sport and exercise sciences, although research in this field has rarely been referred to with the global ‘omics terminology. Commonly studied metabolites in exercise science are notably within cellular pathways for ATP production such as glycolysis (e.g. pyruvate and lactate), β-oxidation of free fatty acids (e.g. palmitate) and ketone bodies (e.g. β-hydroxybutyrate). Non-targeted metabolomic technologies are able to simultaneously analyse the large numbers of metabolites present in human biological samples such as plasma, urine and saliva. These analytical technologies predominately employ nuclear magnetic resonance spectroscopy and chromatography coupled to mass spectrometry. Performing experiments based on non-targeted methods allows for systemic metabolite changes to be analysed and compared to a particular physiological state (e.g. pre/post-exercise) and provides an opportunity to prospect for metabolite signatures that offer beneficial information for translation into an exercise science context, for both elite performance and public health monitoring. This narrative review provides an introduction to non-targeted metabolomic technologies and discusses current and potential applications in sport and exercise science.

Funding

The authors would like to acknowledge the ongoing support from the Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus from Japan Agency for Medical Research and Development (AMED), the University of Tokyo, the John and Lucille van Geest Foundation and the National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit.

History

Citation

Journal of Sports Sciences, 2017

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

Journal of Sports Sciences

Publisher

Taylor & Francis for British Association of Sport and Exercise Sciences

issn

0264-0414

eissn

1466-447X

Acceptance date

08/03/2017

Copyright date

2017

Available date

27/09/2018

Publisher version

http://www.tandfonline.com/doi/full/10.1080/02640414.2017.1305122

Notes

The file associated with this record is under embargo until 18 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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