Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease..pdf (540.15 kB)
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Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease

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posted on 14.07.2015, 12:56 by A. Huertas-Vazquez, C. P. Nelson, X. Guo, K. Reinier, A. Uy-Evanado, C. Teodorescu, J. Ayala, K. Jerger, H. Chugh, WTCCC+, P. S. Braund, P. Deloukas, A. S. Hall, A. J. Balmforth, M. Jones, K. D. Taylor, S. L. Pulit, C. Newton-Cheh, K. Gunson, J. Jui, J. I. Rotter, C. M. Albert, N. J. Samani, S. S. Chugh
BACKGROUND: Recent genome-wide association studies (GWAS) have identified novel loci associated with sudden cardiac death (SCD). Despite this progress, identified DNA variants account for a relatively small portion of overall SCD risk, suggesting that additional loci contributing to SCD susceptibility await discovery. The objective of this study was to identify novel DNA variation associated with SCD in the context of coronary artery disease (CAD). METHODS AND FINDINGS: Using the MetaboChip custom array we conducted a case-control association analysis of 119,117 SNPs in 948 SCD cases (with underlying CAD) from the Oregon Sudden Unexpected Death Study (Oregon-SUDS) and 3,050 controls with CAD from the Wellcome Trust Case-Control Consortium (WTCCC). Two newly identified loci were significantly associated with increased risk of SCD after correction for multiple comparisons at: rs6730157 in the RAB3GAP1 gene on chromosome 2 (P = 4.93×10(-12), OR = 1.60) and rs2077316 in the ZNF365 gene on chromosome 10 (P = 3.64×10(-8), OR = 2.41). CONCLUSIONS: Our findings suggest that RAB3GAP1 and ZNF365 are relevant candidate genes for SCD and will contribute to the mechanistic understanding of SCD susceptibility.

History

Citation

PLoS One, 2013, 8 (4), e59905

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

PLoS One

Publisher

Public Library of Science

eissn

1932-6203

Acceptance date

19/02/2013

Copyright date

2013

Available date

14/07/2015

Publisher version

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059905

Language

en